Recent research highlights from the Jonsson lab
Recent Research Highlights
Granzyme K activates complement cascades
Check out our bioRxiv preprint demonstrating how granzyme K can activate pro-inflammatory complement cascades, a new and important effector function of granzyme K
Classifying the cellular and molecular heterogeneity of rheumatoid arthritis
This large collaborative effort from the Accelerating Medicines Partnership: RA/SLE Network provides an atlas of cells in rheumatoid arthritis synovium and also describes different kinds of RA synovial inflammation.
What are Granzyme K+ CD8 T cells anyway?
In this paper, we provided the first functional characterization of granzyme K-expressing CD8 T cells, the work that forms the foundation of the Jonsson lab.
GzmK are found in lots of autoimmune diseases
Granzyme K is popping up in all kinds of diseases, not just autoimmune diseases but also cancers and infections. Hopefully we’ll have the opportunity to write an even broader review soon!
Rheumatoid arthritis synovium can be inflamed in different ways, and this is likely important for treatment responses
Any practicing rheumatologist (including Helena!) can tell you that not all RA patients are the same, and they don’t all respond to the same medications. We’re starting to understand the cellular and molecular reasons for these differences, but there’s still a lot to learn.
